[HTML][HTML] Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium
HW Chaudhry, NH Dashoush, H Tang, L Zhang… - Journal of Biological …, 2004 - ASBMB
Cell cycle withdrawal limits proliferation of adult mammalian cardiomyocytes. Therefore, the
concept of stimulating myocyte mitotic divisions has dramatic implications for cardiomyocyte
regeneration and hence, cardiovascular disease. Previous reports describing manipulation
of cell cycle proteins have not shown induction of cardiomyocyte mitosis after birth. We now
report that cyclin A2, normally silenced in the postnatal heart, induces cardiac enlargement
because of cardiomyocyte hyperplasia when constitutively expressed from embryonic day 8 …
concept of stimulating myocyte mitotic divisions has dramatic implications for cardiomyocyte
regeneration and hence, cardiovascular disease. Previous reports describing manipulation
of cell cycle proteins have not shown induction of cardiomyocyte mitosis after birth. We now
report that cyclin A2, normally silenced in the postnatal heart, induces cardiac enlargement
because of cardiomyocyte hyperplasia when constitutively expressed from embryonic day 8 …