[HTML][HTML] The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans

JA Zallen, BA Yi, CI Bargmann - Cell, 1998 - cell.com
JA Zallen, BA Yi, CI Bargmann
Cell, 1998cell.com
The C. elegans sax-3 gene encodes a predicted transmembrane protein with five
immunoglobulin domains and three fibronectin type III repeats that is closely related to
Drosophila Robo. Mutations in sax-3 lead to repeated midline crossing by ventral cord
axons that normally do not cross the midline after they join the ventral cord, a phenotype
similar to that of robo mutants. sax-3 is also required for guidance of some axons to the
ventral cord, implicating this gene in two different types of guidance events. A sax-3:: GFP …
Abstract
The C. elegans sax-3 gene encodes a predicted transmembrane protein with five immunoglobulin domains and three fibronectin type III repeats that is closely related to Drosophila Robo. Mutations in sax-3 lead to repeated midline crossing by ventral cord axons that normally do not cross the midline after they join the ventral cord, a phenotype similar to that of robo mutants. sax-3 is also required for guidance of some axons to the ventral cord, implicating this gene in two different types of guidance events. A sax-3::GFP fusion gene is expressed in developing neurons during axon outgrowth, and sax-3 function is required at the time of axon guidance, suggesting that this gene mediates cell interactions during guidance decisions.
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