[HTML][HTML] Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a …
L Sánchez-Cenizo, L Formentini, M Aldea… - Journal of Biological …, 2010 - ASBMB
The H+-ATP synthase is a reversible engine of mitochondria that synthesizes or hydrolyzes
ATP upon changes in cell physiology. ATP synthase dysfunction is involved in the onset and
progression of diverse human pathologies. During ischemia, the ATP hydrolytic activity of
the enzyme is inhibited by the ATPase inhibitory factor 1 (IF1). The expression of IF1 in
human tissues and its participation in the development of human pathology are unknown.
Here, we have developed monoclonal antibodies against human IF1 and determined its …
ATP upon changes in cell physiology. ATP synthase dysfunction is involved in the onset and
progression of diverse human pathologies. During ischemia, the ATP hydrolytic activity of
the enzyme is inhibited by the ATPase inhibitory factor 1 (IF1). The expression of IF1 in
human tissues and its participation in the development of human pathology are unknown.
Here, we have developed monoclonal antibodies against human IF1 and determined its …