All roads lead to PP 2A: exploiting the therapeutic potential of this phosphatase

J Sangodkar, CC Farrington, K McClinch… - The FEBS …, 2016 - Wiley Online Library
J Sangodkar, CC Farrington, K McClinch, MD Galsky, DB Kastrinsky, G Narla
The FEBS journal, 2016Wiley Online Library
Protein phosphatase 2A (PP 2A) is a serine/threonine phosphatase involved in the
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is
genetically altered or functionally inactivated in many cancers highlighting a need for its
therapeutic reactivation. In this review we discuss recent literature on PP 2A: the elucidation
of its structure and the functions of its subunits, and the identification of molecular lesions
and post‐translational modifications leading to its dysregulation in cancer. A final section will …
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase involved in the regulation of many cellular processes. A confirmed tumor suppressor protein, PP2A is genetically altered or functionally inactivated in many cancers highlighting a need for its therapeutic reactivation. In this review we discuss recent literature on PP2A: the elucidation of its structure and the functions of its subunits, and the identification of molecular lesions and post‐translational modifications leading to its dysregulation in cancer. A final section will discuss the proteins and small molecules that modulate PP2A and how these might be used to target dysregulated forms of PP2A to treat cancers and other diseases.
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