[HTML][HTML] The RNA-binding protein HuR regulates the expression of cyclooxygenase-2
S Sengupta, BC Jang, MT Wu, JH Paik… - Journal of Biological …, 2003 - ASBMB
The cyclooxygenase-2 (COX-2) gene encodes the inducible prostaglandin synthase
enzyme implicated in inflammation, cell growth, and tumorigenesis. Regulation of the COX-2
gene expression at the post-transcriptional level is poorly understood. For example, protein
factors that regulate the post-transcriptional mRNA metabolism of COX-2 have not been fully
characterized. In this study, we demonstrate that the RNA-binding protein HuR binds to COX-
2 mRNA and regulates its expression. We show that there are three binding sites for HuR in …
enzyme implicated in inflammation, cell growth, and tumorigenesis. Regulation of the COX-2
gene expression at the post-transcriptional level is poorly understood. For example, protein
factors that regulate the post-transcriptional mRNA metabolism of COX-2 have not been fully
characterized. In this study, we demonstrate that the RNA-binding protein HuR binds to COX-
2 mRNA and regulates its expression. We show that there are three binding sites for HuR in …