[HTML][HTML] The epigenomics of cancer

PA Jones, SB Baylin - Cell, 2007 - cell.com
Cell, 2007cell.com
Aberrant gene function and altered patterns of gene expression are key features of cancer.
Growing evidence shows that acquired epigenetic abnormalities participate with genetic
alterations to cause this dysregulation. Here, we review recent advances in understanding
how epigenetic alterations participate in the earliest stages of neoplasia, including
stem/precursor cell contributions, and discuss the growing implications of these advances
for strategies to control cancer.
Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer.
cell.com