Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease
A Majdi, L Aoudjehane, V Ratziu, T Islam… - Journal of …, 2020 - Elsevier
Background & Aims In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo
necroptosis: a regulated form of necrotic cell death mediated by the receptor-interacting
protein kinase (RIPK) 1. Herein, we assessed the potential for RIPK1 and its downstream
effector mixed lineage kinase domain-like protein (MLKL) to act as therapeutic targets and
markers of activity in NAFLD. Methods C57/BL6J-mice were fed a normal chow diet or a high-
fat diet (HFD). The effect of RIPA-56, a highly specific inhibitor of RIPK1, was evaluated in …
necroptosis: a regulated form of necrotic cell death mediated by the receptor-interacting
protein kinase (RIPK) 1. Herein, we assessed the potential for RIPK1 and its downstream
effector mixed lineage kinase domain-like protein (MLKL) to act as therapeutic targets and
markers of activity in NAFLD. Methods C57/BL6J-mice were fed a normal chow diet or a high-
fat diet (HFD). The effect of RIPA-56, a highly specific inhibitor of RIPK1, was evaluated in …
