Interleukin‐1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
H Tilg, AR Moschen, G Szabo - Hepatology, 2016 - journals.lww.com
Both alcoholic liver disease (ALD) and nonalcoholic fatty liver disease are characterized by
massive lipid accumulation in the liver accompanied by inflammation, fibrosis, cirrhosis, and
hepatocellular carcinoma in a substantial subgroup of patients. At several stages in these
diseases, mediators of the immune system, such as cytokines or inflammasomes, are
crucially involved. In ALD, chronic ethanol exposure sensitizes Kupffer cells to activation by
lipopolysaccharides through Toll‐like receptors, eg, Toll‐like receptor 4. This sensitization …
massive lipid accumulation in the liver accompanied by inflammation, fibrosis, cirrhosis, and
hepatocellular carcinoma in a substantial subgroup of patients. At several stages in these
diseases, mediators of the immune system, such as cytokines or inflammasomes, are
crucially involved. In ALD, chronic ethanol exposure sensitizes Kupffer cells to activation by
lipopolysaccharides through Toll‐like receptors, eg, Toll‐like receptor 4. This sensitization …
