The inflammatory signal adaptor RIPK3: functions beyond necroptosis
K Moriwaki, FKM Chan - International review of cell and molecular biology, 2017 - Elsevier
Receptor interacting protein kinase 3 (RIPK3) is an essential serine/threonine kinase for
necroptosis, a type of regulated necrosis. A variety of stimuli can cause RIPK3 activation
through phosphorylation. Activated RIPK3 in turn phosphorylates and activates the
downstream necroptosis executioner mixed lineage kinase domain-like (MLKL). Necroptosis
is a highly inflammatory type of cell death because of the release of intracellular
immunogenic contents from disrupted plasma membrane. Indeed, RIPK3-deficient mice …
necroptosis, a type of regulated necrosis. A variety of stimuli can cause RIPK3 activation
through phosphorylation. Activated RIPK3 in turn phosphorylates and activates the
downstream necroptosis executioner mixed lineage kinase domain-like (MLKL). Necroptosis
is a highly inflammatory type of cell death because of the release of intracellular
immunogenic contents from disrupted plasma membrane. Indeed, RIPK3-deficient mice …