MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis
X Wu, KL Poulsen, C Sanz-Garcia, E Huang… - Journal of …, 2020 - Elsevier
Background & Aims Autophagy maintains cellular homeostasis and plays a critical role in
the development of non-alcoholic fatty liver and steatohepatitis. The pseudokinase mixed
lineage kinase domain-like (MLKL) is a key downstream effector of receptor interacting
protein kinase 3 (RIP3) in the necroptotic pathway of programmed cell death. However,
recent data reveal that MLKL also regulates autophagy. Herein, we tested the hypothesis
that MLKL contributes to the progression of Western diet-induced liver injury in mice by …
the development of non-alcoholic fatty liver and steatohepatitis. The pseudokinase mixed
lineage kinase domain-like (MLKL) is a key downstream effector of receptor interacting
protein kinase 3 (RIP3) in the necroptotic pathway of programmed cell death. However,
recent data reveal that MLKL also regulates autophagy. Herein, we tested the hypothesis
that MLKL contributes to the progression of Western diet-induced liver injury in mice by …
