Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity
N Kaplowitz, S Win, TA Than, ZX Liu… - Journal of …, 2015 - journal-of-hepatology.eu
Acetaminophen (APAP) is a widely used medication which has been associated with dose-
dependent liver injury and is the leading cause of acute liver failure in the US and most of
Europe [1]. Because of its highly reproducible effects in rodents, it has served as a model
hepatotoxin for more than forty years. A great deal of information about the mechanism of its
toxic effect has been gained over this period, although research continues on the details of
several aspects of the cell death and tissue injury process. To summarize some of the …
dependent liver injury and is the leading cause of acute liver failure in the US and most of
Europe [1]. Because of its highly reproducible effects in rodents, it has served as a model
hepatotoxin for more than forty years. A great deal of information about the mechanism of its
toxic effect has been gained over this period, although research continues on the details of
several aspects of the cell death and tissue injury process. To summarize some of the …
