Comparison of regulatory T cells in hemodialysis patients and healthy controls: implications for cell therapy in transplantation
B Afzali, FC Edozie, H Fazekasova… - Clinical Journal of the …, 2013 - journals.lww.com
Results Both groups had similar total regulatory T cells and subpopulations I and III. In each
subpopulation, regulatory T cells expressed similar levels of the function-associated markers
CD27, CD39, HLA-DR, and FOXP3. Hemodialysis regulatory T cells were less suppressive,
expanded poorly compared with healthy control regulatory T cells, and produced IL-17 in the
absence of Rapamycin. However, Rapamycin efficiently expanded hemodialysis regulatory
T cells to a functional and stable cell product. Conclusions Rapamycin-based expansion …
subpopulation, regulatory T cells expressed similar levels of the function-associated markers
CD27, CD39, HLA-DR, and FOXP3. Hemodialysis regulatory T cells were less suppressive,
expanded poorly compared with healthy control regulatory T cells, and produced IL-17 in the
absence of Rapamycin. However, Rapamycin efficiently expanded hemodialysis regulatory
T cells to a functional and stable cell product. Conclusions Rapamycin-based expansion …