Detection of the BRAF V600E mutation in serous ovarian tumors: a comparative analysis of immunohistochemistry with a mutation-specific monoclonal antibody and …
H Bösmüller, A Fischer, DL Pham, T Fehm, D Capper… - Human pathology, 2013 - Elsevier
Mutations of components of the mitogen-activated protein kinase pathway, mainly BRAF, are
common in serous ovarian borderline tumors, whereas high-grade serous ovarian
carcinomas rarely show this feature. With the advent of specific kinase inhibitors active
against BRAF-mutated cancers, rapid and sensitive detection of the BRAF V600E, by far the
most common mutation of this gene, is of great practical relevance. Currently, BRAF
mutations are detected by DNA-based techniques. Recently, a monoclonal antibody (VE1) …
common in serous ovarian borderline tumors, whereas high-grade serous ovarian
carcinomas rarely show this feature. With the advent of specific kinase inhibitors active
against BRAF-mutated cancers, rapid and sensitive detection of the BRAF V600E, by far the
most common mutation of this gene, is of great practical relevance. Currently, BRAF
mutations are detected by DNA-based techniques. Recently, a monoclonal antibody (VE1) …