Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone–independent hypocalciuria

HR Toka, K Al-Romaih, JM Koshy… - Journal of the …, 2012 - journals.lww.com
Rare loss-of-function mutations in the calcium-sensing receptor (Casr) gene lead to
decreased urinary calcium excretion in the context of parathyroid hormone (PTH)–
dependent hypercalcemia, but the role of Casr in the kidney is unknown. Using animals
expressing Cre recombinase driven by the Six2 promoter, we generated mice that appeared
grossly normal but had undetectable levels of Casr mRNA and protein in the kidney.
Baseline serum calcium, phosphorus, magnesium, and PTH levels were similar to control …