The lung in sickle cell disease
HM Haupt, GW Moore, TW Bauer, GM Hutchins - Chest, 1982 - Elsevier
Patients with sickle cell disease (SCD) often present with acute pulmonary complications,
which may have a protracted course. Morphologic observations of SCD patients at autopsy
suggested a role of tissue necrosis in the failure of pulmonary infiltrates to resolve with
therapy. Infarction of pulmonary parenchyma was seen in regions where alveolar gas
exchange was compromised by edema or exudates. We reviewed the clinical and
pathologic features of 72 patients with sickle cell disease (59 SS, 12 SC, and 1 S-Thal) …
which may have a protracted course. Morphologic observations of SCD patients at autopsy
suggested a role of tissue necrosis in the failure of pulmonary infiltrates to resolve with
therapy. Infarction of pulmonary parenchyma was seen in regions where alveolar gas
exchange was compromised by edema or exudates. We reviewed the clinical and
pathologic features of 72 patients with sickle cell disease (59 SS, 12 SC, and 1 S-Thal) …