GSK-3β acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2
AK Jain, AK Jaiswal - Journal of Biological Chemistry, 2007 - ASBMB
NF-E2-related factor 2 (Nrf2) regulates expression and coordinated induction of a battery of
chemoprotective genes in response to oxidative and electrophilic stress. This leads to
protection against oxidative stress and neoplastic diseases. Nuclear import and export of
Nrf2 play a significant role in control of nuclear levels of Nrf2 and thus the expression of Nrf2
down-stream genes. Tyrosine kinase Fyn phosphorylates tyrosine 568 of Nrf2 that leads to
the nuclear export of Nrf2. In this study, we investigated the upstream factor (s) in regulation …
chemoprotective genes in response to oxidative and electrophilic stress. This leads to
protection against oxidative stress and neoplastic diseases. Nuclear import and export of
Nrf2 play a significant role in control of nuclear levels of Nrf2 and thus the expression of Nrf2
down-stream genes. Tyrosine kinase Fyn phosphorylates tyrosine 568 of Nrf2 that leads to
the nuclear export of Nrf2. In this study, we investigated the upstream factor (s) in regulation …
