Quantifying the material and structural determinants of bone strength

ML Bouxsein, E Seeman - Best practice & research Clinical rheumatology, 2009 - Elsevier
The ability of a bone to resist fracture depends on the amount of bone present, the spatial
distribution of the bone mass as cortical and trabecular bone and the intrinsic properties of
the bone material. Whereas low areal bone mineral density (aBMD) predicts fractures, its
sensitivity and specificity is low, as over 50% of fractures occur in persons without
osteoporosis by BMD testing and most women with osteoporosis do not sustain a fracture.
New non-invasive imaging techniques, including three-dimensional (3D) assessments of …