Alterations in the contractile phenotype of the bladder: lessons for understanding physiological and pathological remodelling of smooth muscle
SA Zderic, S Chacko - Journal of cellular and molecular …, 2012 - Wiley Online Library
SA Zderic, S Chacko
Journal of cellular and molecular medicine, 2012•Wiley Online LibraryIntroduction• Alterations in bladder contractility with normal development• Assessment of
bladder function in genetically modified mice• A whole organ perspective on the bladder's
response to pBOO‐Clinical observations• Experimental observations• In vivo measures of
pBOO in a rabbit model• Relating muscle strip studies to whole organ function• Myosin light
chain phosphorylation• Regulation of myosin light chain de‐phosphorylation• Alterations in
the thick contractile filaments‐SM1 and SM2 isoforms‐SM‐B and SM‐A isoforms• …
bladder function in genetically modified mice• A whole organ perspective on the bladder's
response to pBOO‐Clinical observations• Experimental observations• In vivo measures of
pBOO in a rabbit model• Relating muscle strip studies to whole organ function• Myosin light
chain phosphorylation• Regulation of myosin light chain de‐phosphorylation• Alterations in
the thick contractile filaments‐SM1 and SM2 isoforms‐SM‐B and SM‐A isoforms• …
Abstract
- • Introduction
- • Alterations in bladder contractility with normal development
- • Assessment of bladder function in genetically modified mice
- • A whole organ perspective on the bladder’s response to pBOO
- ‐ Clinical observations
- ‐
- • Experimental observations
- • In vivo measures of pBOO in a rabbit model
- • Relating muscle strip studies to whole organ function
- • Myosin light chain phosphorylation
- • Regulation of myosin light chain de‐phosphorylation
- • Alterations in the thick contractile filaments
- ‐ SM1 and SM2 isoforms
- ‐ SM‐B and SM‐A isoforms
- ‐
- • Regulatory light chain
- • Alterations in the thin contractile filaments
- • Alterations in tension transfer complex
The contractile properties of the urinary bladder are changed by the conditions of normal development and partial bladder outlet obstruction. This change in the contractile phenotype is accompanied by changes in the regulatory cascades and filaments that regulate contractility. This review focuses on such changes during the course of normal development and in response to obstruction. Our goal is to discuss the experimental evidence that has accumulated from work in animal models and correlate these findings with the human voiding phenotype.
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