Semaphorin‐induced cytoskeletal collapse and repulsion of endothelial cells
DR Bielenberg, A Shimizu, M Klagsbrun - Methods in enzymology, 2008 - Elsevier
Abstract Class 3 semaphorins (SEMA3) are mediators of neuronal guidance first shown to
repel axons and collapse axonal growth cones by depolymerization of cytoskeletal F‐actin.
Subsequently, it was found that SEMA3 could also mediate angiogenesis. SEMA3F binds to
its receptor, neuropilin 2 (NRP2), a transmembrane protein expressed on neurons, EC (EC),
and tumor cells. In vitro, SEMA3F collapses the F‐actin cytoskeleton, repels EC, and inhibits
EC and tumor cell adhesion and migration in a manner similar to what occurs with axons. In …
repel axons and collapse axonal growth cones by depolymerization of cytoskeletal F‐actin.
Subsequently, it was found that SEMA3 could also mediate angiogenesis. SEMA3F binds to
its receptor, neuropilin 2 (NRP2), a transmembrane protein expressed on neurons, EC (EC),
and tumor cells. In vitro, SEMA3F collapses the F‐actin cytoskeleton, repels EC, and inhibits
EC and tumor cell adhesion and migration in a manner similar to what occurs with axons. In …
