[HTML][HTML] Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen …
MA Shields, S Dangi-Garimella, SB Krantz… - Journal of Biological …, 2011 - ASBMB
Pancreatic ductal adenocarcinoma (PDAC) is characterized by pronounced fibrotic reaction
composed primarily of type I collagen. Although type I collagen functions as a barrier to
invasion, pancreatic cancer cells have been shown to respond to type I collagen by
becoming more motile and invasive. Because epithelial-mesenchymal transition is also
associated with cancer invasion, we examined the extent to which collagen modulated the
expression of Snail, a well known regulator of epithelial-mesenchymal transition. Relative to …
composed primarily of type I collagen. Although type I collagen functions as a barrier to
invasion, pancreatic cancer cells have been shown to respond to type I collagen by
becoming more motile and invasive. Because epithelial-mesenchymal transition is also
associated with cancer invasion, we examined the extent to which collagen modulated the
expression of Snail, a well known regulator of epithelial-mesenchymal transition. Relative to …