[HTML][HTML] Beta-adrenoceptor regulates miRNA expression in rat heart
Y Hou, Y Sun, H Shan, X Li, M Zhang… - … medical journal of …, 2012 - ncbi.nlm.nih.gov
Y Hou, Y Sun, H Shan, X Li, M Zhang, X Zhou, S Xing, H Sun, W Chu, G Qiao, Y Lu
Medical science monitor: international medical journal of experimental …, 2012•ncbi.nlm.nih.govBackground MicroRNAs (miRNAs) are noncoding RNAs of 18–25 nucleotides that post-
transcriptionally regulate gene expression and are involved in a wide range of physiological
and pathological conditions. The β-adrenergic signaling pathway plays a fundamental role
in regulation of heart function. The present study was designed to investigate the expression
profile of miRNAs and functional implications under conditions of β-adrenoceptor activation
or inhibition in rat heart.
transcriptionally regulate gene expression and are involved in a wide range of physiological
and pathological conditions. The β-adrenergic signaling pathway plays a fundamental role
in regulation of heart function. The present study was designed to investigate the expression
profile of miRNAs and functional implications under conditions of β-adrenoceptor activation
or inhibition in rat heart.
Summary
Background
MicroRNAs (miRNAs) are noncoding RNAs of 18–25 nucleotides that post-transcriptionally regulate gene expression and are involved in a wide range of physiological and pathological conditions. The β-adrenergic signaling pathway plays a fundamental role in regulation of heart function. The present study was designed to investigate the expression profile of miRNAs and functional implications under conditions of β-adrenoceptor activation or inhibition in rat heart.
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