Pulmonary complications of sickle cell disease

AC Miller, MT Gladwin - American journal of respiratory and critical …, 2012 - atsjournals.org
AC Miller, MT Gladwin
American journal of respiratory and critical care medicine, 2012atsjournals.org
Sickle cell disease (SCD) is a common monogenetic disorder with high associated morbidity
and mortality. The pulmonary complications of SCD are of particular importance, as acute
chest syndrome and pulmonary hypertension have the highest associated mortality rates
within this population. This article reviews the pathophysiology, diagnosis, and treatment of
clinically significant pulmonary manifestations of SCD, including acute chest syndrome,
asthma, and pulmonary hypertension in adult and pediatric patients. Clinicians should be …
Sickle cell disease (SCD) is a common monogenetic disorder with high associated morbidity and mortality. The pulmonary complications of SCD are of particular importance, as acute chest syndrome and pulmonary hypertension have the highest associated mortality rates within this population. This article reviews the pathophysiology, diagnosis, and treatment of clinically significant pulmonary manifestations of SCD, including acute chest syndrome, asthma, and pulmonary hypertension in adult and pediatric patients. Clinicians should be vigilant in screening and treating such comorbidities to improve patient outcomes.
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