The prostate gland contains a heterogeneous milieu of stromal, epithelial, neuroendocrine
and immune cell types. Healthy prostate is comprised of fibromuscular stroma surrounding
discrete epithelial-lined secretory lumens and a very small population of immune and
neuroendocrine cells. In contrast, areas of prostate cancer have increased dysplastic
luminal epithelium with greatly reduced or absent stromal population. Given the profound
difference between stromal and epithelial cell types, it is imperative to separate the cell types …