Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention

MR Haussler, CA Haussler, L Bartik… - Nutrition …, 2008 - academic.oup.com
MR Haussler, CA Haussler, L Bartik, GK Whitfield, JC Hsieh, S Slater, PW Jurutka
Nutrition reviews, 2008academic.oup.com
The human vitamin D receptor (VDR) is a key nuclear receptor that binds nutritionally
derived ligands and exerts bioeffects that contribute to bone mineral homeostasis,
detoxification of exogenous and endogenous compounds, cancer prevention, and
mammalian hair cycling. Liganded VDR modulates gene expression via heterodimerization
with the retinoid X receptor and recruitment of coactivators or corepressors. VDR interacts
with the corepressor hairless (Hr) to control hair cycling, an action independent of the …
Abstract
The human vitamin D receptor (VDR) is a key nuclear receptor that binds nutritionally derived ligands and exerts bioeffects that contribute to bone mineral homeostasis, detoxification of exogenous and endogenous compounds, cancer prevention, and mammalian hair cycling. Liganded VDR modulates gene expression via heterodimerization with the retinoid X receptor and recruitment of coactivators or corepressors. VDR interacts with the corepressor hairless (Hr) to control hair cycling, an action independent of the endocrine VDR ligand, 1,25-dihydroxyvitamin D3. We report novel dietary ligands for VDR including curcumin, γ-tocotrienol, and essential fatty acid derivatives that likely play a role in the bioactions of VDR.
Oxford University Press