[HTML][HTML] Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease

MF Holick - The American journal of clinical nutrition, 2004 - Elsevier
Most humans depend on sun exposure to satisfy their requirements for vitamin D. Solar
ultraviolet B photons are absorbed by 7-dehydrocholesterol in the skin, leading to its
transformation to previtamin D 3, which is rapidly converted to vitamin D 3. Season, latitude,
time of day, skin pigmentation, aging, sunscreen use, and glass all influence the cutaneous
production of vitamin D 3. Once formed, vitamin D 3 is metabolized in the liver to 25-
hydroxyvitamin D 3 and then in the kidney to its biologically active form, 1, 25 …