[HTML][HTML] Tumor cells enhance their own CD44 cleavage and motility by generating hyaluronan fragments
KN Sugahara, T Hirata, H Hayasaka, R Stern… - Journal of Biological …, 2006 - ASBMB
Hyaluronan (HA) is an extracellular matrix glycosaminoglycan that interacts with cell-surface
receptors, including CD44. Although HA usually exists as a high molecular mass polymer,
HA of a much lower molecular mass that shows a variety of biological activities can be
detected under certain pathological conditions, particularly in tumors. We previously
reported that low molecular weight HAs (LMW-HAs) of a certain size range induce the
proteolytic cleavage of CD44 from the surface of tumor cells and promote tumor cell …
receptors, including CD44. Although HA usually exists as a high molecular mass polymer,
HA of a much lower molecular mass that shows a variety of biological activities can be
detected under certain pathological conditions, particularly in tumors. We previously
reported that low molecular weight HAs (LMW-HAs) of a certain size range induce the
proteolytic cleavage of CD44 from the surface of tumor cells and promote tumor cell …