[HTML][HTML] HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity
G Lepperdinger, B Strobl, G Kreil - Journal of Biological Chemistry, 1998 - ASBMB
Using Expressed Sequence Tags (ESTs) deposited in the data banks, a cDNA has been
assembled that encodes a protein related to the hyaluronidases from bee venom and
mammalian sperm. Expression of this cDNA yielded a polypeptide termed HYAL2, which is
located in lysosomes. The HYAL2 protein was shown to have hyaluronidase activity below
pH 4. However, it only hydrolyzed hyaluronan of high molecular mass from umbilical cord,
rooster comb, and a Streptococcus strain. The reaction product was a polysaccharide of …
assembled that encodes a protein related to the hyaluronidases from bee venom and
mammalian sperm. Expression of this cDNA yielded a polypeptide termed HYAL2, which is
located in lysosomes. The HYAL2 protein was shown to have hyaluronidase activity below
pH 4. However, it only hydrolyzed hyaluronan of high molecular mass from umbilical cord,
rooster comb, and a Streptococcus strain. The reaction product was a polysaccharide of …