A human monoclonal antibody targeting the conserved staphylococcal antigen IsaA protects mice against Staphylococcus aureus bacteremia
S van den Berg, HPJ Bonarius, KPM van Kessel… - International Journal of …, 2015 - Elsevier
Due to substantial therapy failure and the emergence of antibiotic-resistant Staphylococcus
aureus strains, alternatives for antibiotic treatment of S. aureus infections are urgently
needed. Passive immunization using S. aureus-specific monoclonal antibodies (mAb) could
be such an alternative to prevent and treat severe S. aureus infections. The invariantly
expressed immunodominant staphylococcal antigen A (IsaA) is a promising target for
passive immunization. Here we report the development of the human anti-IsaA IgG1 mAb …
aureus strains, alternatives for antibiotic treatment of S. aureus infections are urgently
needed. Passive immunization using S. aureus-specific monoclonal antibodies (mAb) could
be such an alternative to prevent and treat severe S. aureus infections. The invariantly
expressed immunodominant staphylococcal antigen A (IsaA) is a promising target for
passive immunization. Here we report the development of the human anti-IsaA IgG1 mAb …
