In the past 10 years, there has been a lot of enthusiasm surrounding the use of serum
hepatitis B surface antigen (HBsAg) quantification to predict disease activity and monitor
treatment response in chronic hepatitis B. The measurement of HBsAg levels have been
standardized in IU/ml, and nowadays it is almost a mandatory measurement due to the
development of new antiviral treatments aiming at HBsAg seroclearance, ie, functional cure
of hepatitis B. Recently, there has been an improved understanding of the molecular …