Adoptive immunotherapy for cancer: harnessing the T cell response

NP Restifo, ME Dudley, SA Rosenberg - Nature Reviews Immunology, 2012 - nature.com
Nature Reviews Immunology, 2012nature.com
Immunotherapy based on the adoptive transfer of naturally occurring or gene-engineered T
cells can mediate tumour regression in patients with metastatic cancer. Here, we discuss
progress in the use of adoptively transferred T cells, focusing on how they can mediate
tumour cell eradication. Recent advances include more accurate targeting of antigens
expressed by tumours and the associated vasculature, and the successful use of gene
engineering to re-target T cells before their transfer into the patient. We also describe how …
Abstract
Immunotherapy based on the adoptive transfer of naturally occurring or gene-engineered T cells can mediate tumour regression in patients with metastatic cancer. Here, we discuss progress in the use of adoptively transferred T cells, focusing on how they can mediate tumour cell eradication. Recent advances include more accurate targeting of antigens expressed by tumours and the associated vasculature, and the successful use of gene engineering to re-target T cells before their transfer into the patient. We also describe how new research has helped to identify the particular T cell subsets that can most effectively promote tumour eradication.
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