Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis
BACKGROUND & AIMS: Upon exercise, primary biliary cirrhosis (PBC) is associated with
significant acidosis in peripheral muscle with recovery rate from acidosis strongly
associating with fatigue. PBC patients describe particular problems with repeat exercise
describing subsequent exercise episodes being limited by perceived effects of the first. We
modelled this effect by exploring kinetics of pH recovery during 3 linked exercise episodes
using magnetic resonance spectroscopy (MRS). METHODS: Muscle acid handling capacity …
significant acidosis in peripheral muscle with recovery rate from acidosis strongly
associating with fatigue. PBC patients describe particular problems with repeat exercise
describing subsequent exercise episodes being limited by perceived effects of the first. We
modelled this effect by exploring kinetics of pH recovery during 3 linked exercise episodes
using magnetic resonance spectroscopy (MRS). METHODS: Muscle acid handling capacity …