Essential roles of SHPS-1 in induction of contact hypersensitivity of skin
SHPS-1 is a transmembrane protein that binds the protein tyrosine phosphatases SHP-1
and SHP-2 and is abundant on the surface of CD11c+ dendritic cells (DCs). We recently
showed that SHPS-1 is essential for priming by DCs of CD4+ T cells and for development of
Th17 cell-mediated experimental autoimmunity. We have now further evaluated the
importance of SHPS-1 and that of its ligand CD47 in contact hypersensitivity (CHS) to 2, 4-
dinitro-1-fluorobenzene (DNFB). Whereas the DNFB-induced CHS response was impaired …
and SHP-2 and is abundant on the surface of CD11c+ dendritic cells (DCs). We recently
showed that SHPS-1 is essential for priming by DCs of CD4+ T cells and for development of
Th17 cell-mediated experimental autoimmunity. We have now further evaluated the
importance of SHPS-1 and that of its ligand CD47 in contact hypersensitivity (CHS) to 2, 4-
dinitro-1-fluorobenzene (DNFB). Whereas the DNFB-induced CHS response was impaired …