[HTML][HTML] Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts
D Lu, PA Insel - Journal of biological chemistry, 2013 - ASBMB
The establishment of set points for cellular activities is essential in regulating homeostasis.
Here, we demonstrate key determinants of the fibrogenic set point of cardiac fibroblasts
(CFs) by focusing on the pro-fibrotic activity of ATP, which is released by CFs. We tested the
hypothesis that the hydrolysis of extracellular ATP by ectonucleoside triphosphate
diphosphohydrolases (ENTPDs) regulates pro-fibrotic nucleotide signaling. We detected two
ENTPD isoforms, ENTPD-1 and-2, in adult rat ventricular CFs. Partial knockdown of ENTPD …
Here, we demonstrate key determinants of the fibrogenic set point of cardiac fibroblasts
(CFs) by focusing on the pro-fibrotic activity of ATP, which is released by CFs. We tested the
hypothesis that the hydrolysis of extracellular ATP by ectonucleoside triphosphate
diphosphohydrolases (ENTPDs) regulates pro-fibrotic nucleotide signaling. We detected two
ENTPD isoforms, ENTPD-1 and-2, in adult rat ventricular CFs. Partial knockdown of ENTPD …