Chloroquine sensitivity of isolates of Plasmodium falciparum adapted to in vitro culture.
T Ponnudurai, AD Leeuwenberg… - Tropical and …, 1981 - europepmc.org
T Ponnudurai, AD Leeuwenberg, JH Meuwissen
Tropical and geographical medicine, 1981•europepmc.orgThirteen isolates of Plasmodium falciparum obtained from cases of malaria imported into the
Netherlands and established in culture were tested for their sensitivity to chloroquine.
Reproducibility of the test results depended on the exposure of a standardized number of
parasites in culture to the drug. The maximum activity of chloroquine was obtained when
medium with the drug was added to parasite cultures twice at 24 hour intervals. The result of
drug action over a period of 48 hours was estimated best when parasites were counted 72 …
Netherlands and established in culture were tested for their sensitivity to chloroquine.
Reproducibility of the test results depended on the exposure of a standardized number of
parasites in culture to the drug. The maximum activity of chloroquine was obtained when
medium with the drug was added to parasite cultures twice at 24 hour intervals. The result of
drug action over a period of 48 hours was estimated best when parasites were counted 72 …
Thirteen isolates of Plasmodium falciparum obtained from cases of malaria imported into the Netherlands and established in culture were tested for their sensitivity to chloroquine. Reproducibility of the test results depended on the exposure of a standardized number of parasites in culture to the drug. The maximum activity of chloroquine was obtained when medium with the drug was added to parasite cultures twice at 24 hour intervals. The result of drug action over a period of 48 hours was estimated best when parasites were counted 72 hours after the commencement of the test. Sensitivity to chloroquine could not provide a basis for the characterisation of strains.
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