Arylhydrocarbon receptor (AhR) activation in airway epithelial cells induces MUC5AC via reactive oxygen species (ROS) production
T Chiba, H Uchi, G Tsuji, H Gondo, Y Moroi… - Pulmonary pharmacology …, 2011 - Elsevier
The dioxins and dioxin-like compounds in cigarette smoke regulate various immunological
responses via the arylhydrocarbon receptor (AhR). These environmental toxicants are
known to cause bronchitis, asthma, chronic obstructive pulmonary disease (COPD), and
lung cancer. Recent studies have demonstrated that AhR activation upregulates the
expression of mucin 5AC, oligomeric mucus/gel-forming (MUC5AC) in the airway epithelial
cell line. However, the mechanism for the production of mucin has not been clarified. In this …
responses via the arylhydrocarbon receptor (AhR). These environmental toxicants are
known to cause bronchitis, asthma, chronic obstructive pulmonary disease (COPD), and
lung cancer. Recent studies have demonstrated that AhR activation upregulates the
expression of mucin 5AC, oligomeric mucus/gel-forming (MUC5AC) in the airway epithelial
cell line. However, the mechanism for the production of mucin has not been clarified. In this …