[HTML][HTML] GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche
Y Shiozawa, EA Pedersen, RS Taichman - Experimental hematology, 2010 - Elsevier
OBJECTIVE: Despite improvements in current combinational chemotherapy regimens, the
prognosis of the (1; 19)(q23; p13) translocation (E2A/PBX1)− positive B-cell precursor acute
lymphoblastic leukemia (ALL) is poor in pediatric leukemia patients. MATERIALS AND
METHODS: In this study, we examined the roles of growth arrest− specific-6 (GAS6)/Mer axis
in the interactions between E2A/PBX1-positive B-cell precursor ALL cells and the
osteoblastic niche in the bone marrow. RESULTS: Data show that primary human …
prognosis of the (1; 19)(q23; p13) translocation (E2A/PBX1)− positive B-cell precursor acute
lymphoblastic leukemia (ALL) is poor in pediatric leukemia patients. MATERIALS AND
METHODS: In this study, we examined the roles of growth arrest− specific-6 (GAS6)/Mer axis
in the interactions between E2A/PBX1-positive B-cell precursor ALL cells and the
osteoblastic niche in the bone marrow. RESULTS: Data show that primary human …