[HTML][HTML] Differential regulation of vascular endothelial growth factor expression by peroxisome proliferator-activated receptors in bladder cancer cells
S Fauconnet, I Lascombe, E Chabannes… - Journal of Biological …, 2002 - ASBMB
The growth of any solid tumor depends on angiogenesis. Vascular endothelial growth factor
(VEGF) plays a prominent role in vesical tumor angiogenesis regulation. Previous studies
have shown that the peroxisome proliferator-activated receptor γ (PPARγ) was involved in
the angiogenesis process. Here, we report for the first time that in two different human
bladder cancer cell lines, RT4 (derived from grade I tumor) and T24 (derived from grade III
tumor), VEGF (mRNA and protein) is differentially up-regulated by the three PPAR isotypes …
(VEGF) plays a prominent role in vesical tumor angiogenesis regulation. Previous studies
have shown that the peroxisome proliferator-activated receptor γ (PPARγ) was involved in
the angiogenesis process. Here, we report for the first time that in two different human
bladder cancer cell lines, RT4 (derived from grade I tumor) and T24 (derived from grade III
tumor), VEGF (mRNA and protein) is differentially up-regulated by the three PPAR isotypes …