Increases in nuclear p65 activation in dystrophic skeletal muscle are secondary to increases in the cellular expression of p65 and are not solely produced by …
R Singh, G Millman, E Turin, L Polisiakeiwicz… - Journal of the …, 2009 - Elsevier
Dystrophin-deficient muscle exhibits substantial increases in nuclear NF-κB activation. To
examine potential mechanisms for this enhanced activation, the present study employs
conventional Western blot techniques to provide the first determination of the relative
expression of NF-κB signaling molecules in adult nondystrophic and dystrophic (mdx)
skeletal muscle. The results indicate that dystrophic muscle is characterized by increases in
the whole cell expression of IκB-α, p65, p50, RelB, p100, p52, IKK, and TRAF-3. The …
examine potential mechanisms for this enhanced activation, the present study employs
conventional Western blot techniques to provide the first determination of the relative
expression of NF-κB signaling molecules in adult nondystrophic and dystrophic (mdx)
skeletal muscle. The results indicate that dystrophic muscle is characterized by increases in
the whole cell expression of IκB-α, p65, p50, RelB, p100, p52, IKK, and TRAF-3. The …