Role of plasminogen in macrophage accumulation during liver repair
N Kawao, N Nagai, K Okada, K Okumoto, S Ueshima… - Thrombosis research, 2010 - Elsevier
INTRODUCTION: Although the involvement of plasminogen in liver repair has been
reported, its roles are still poorly understood. Here, we investigated the role of plasminogen
in accumulations of macrophages and neutrophils after liver injury in mice with gene
deficient of plasminogen (Plg−/−) or its wild type (Plg+/+). MATERIALS AND METHODS:
Mice received traumatic liver injury caused by stabbing on the lobe or hepatic ischemia-
reperfusion, and the damaged sites were histologically analyzed. RESULTS: After the …
reported, its roles are still poorly understood. Here, we investigated the role of plasminogen
in accumulations of macrophages and neutrophils after liver injury in mice with gene
deficient of plasminogen (Plg−/−) or its wild type (Plg+/+). MATERIALS AND METHODS:
Mice received traumatic liver injury caused by stabbing on the lobe or hepatic ischemia-
reperfusion, and the damaged sites were histologically analyzed. RESULTS: After the …
