[HTML][HTML] Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet β-cells
MK Lingohr, I Briaud, LM Dickson, JF McCuaig… - Journal of Biological …, 2006 - ASBMB
Insulin receptor substrate 2 (IRS-2) plays a critical role in pancreatic β-cells. Increased IRS-2
expression promotes β-cell growth and survival, whereas decreased IRS-2 levels lead to
apoptosis. It was found that IRS-2 turnover in rat islet β-cells was rapid, with mRNA and
protein half-lives of∼ 90 min and∼ 2 h, respectively. However, this was countered by
specific glucose-regulated IRS-2 expression mediated at the transcriptional level. Glucose
(≥ 6 mm) increased IRS-2 mRNA and protein levels in a dose-dependent manner, reaching …
expression promotes β-cell growth and survival, whereas decreased IRS-2 levels lead to
apoptosis. It was found that IRS-2 turnover in rat islet β-cells was rapid, with mRNA and
protein half-lives of∼ 90 min and∼ 2 h, respectively. However, this was countered by
specific glucose-regulated IRS-2 expression mediated at the transcriptional level. Glucose
(≥ 6 mm) increased IRS-2 mRNA and protein levels in a dose-dependent manner, reaching …