[HTML][HTML] The α-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein–coupled receptor lysosomal sorting and signaling
Aberrant G protein–coupled receptor (GPCR) expression and activation has been linked to
tumor initiation, progression, invasion, and metastasis. However, compared with other
cancer drivers, the exploitation of GPCRs as potential therapeutic targets has been largely
ignored, despite the fact that GPCRs are highly druggable. Therefore, to advance the
potential status of GPCRs as therapeutic targets, it is important to understand how GPCRs
function together with other cancer drivers during tumor progression. We now report that the …
tumor initiation, progression, invasion, and metastasis. However, compared with other
cancer drivers, the exploitation of GPCRs as potential therapeutic targets has been largely
ignored, despite the fact that GPCRs are highly druggable. Therefore, to advance the
potential status of GPCRs as therapeutic targets, it is important to understand how GPCRs
function together with other cancer drivers during tumor progression. We now report that the …
