Unique glandular ex-vivo Th1 and Th17 receptor motifs in Sjögren's syndrome patients using single-cell analysis
A Voigt, K Bohn, S Sukumaran, CM Stewart… - Clinical …, 2018 - Elsevier
Primary Sjögren's syndrome (pSS) is an autoimmune disease in which the underlying cause
has yet to be elucidated. The main objective of this study was to determine the T cell
receptor (TCR) repertoires of individual infiltrating T helper (Th)-1 and 17 cells of pSS
patients using single-cell analysis. Single-cell analysis of ex-vivo infiltrating T cells
demonstrated that pSS patients had higher frequencies of activated Th17 cells. Single-cell
TCR sequencing revealed that TCRβ variable (TRBV) 3-1/joint (J) 1-2 (CLFLSMSACVW) …
has yet to be elucidated. The main objective of this study was to determine the T cell
receptor (TCR) repertoires of individual infiltrating T helper (Th)-1 and 17 cells of pSS
patients using single-cell analysis. Single-cell analysis of ex-vivo infiltrating T cells
demonstrated that pSS patients had higher frequencies of activated Th17 cells. Single-cell
TCR sequencing revealed that TCRβ variable (TRBV) 3-1/joint (J) 1-2 (CLFLSMSACVW) …
