Recognition of viral and self-antigens by TH1 and TH1/TH17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and …
M Paroni, V Maltese, M De Simone, V Ranzani… - Journal of Allergy and …, 2017 - Elsevier
Background Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central
nervous system (CNS) that is caused by autoreactive T cells and associated with viral
infections. However, the phenotype of pathogenic T cells in peripheral blood remains to be
defined, and how viruses promote MS is debated. Objective We aimed to identify and
characterize potentially pathogenic autoreactive T cells, as well as protective antiviral T
cells, in patients with MS. Methods We analyzed CD4+ helper T-cell subsets from peripheral …
nervous system (CNS) that is caused by autoreactive T cells and associated with viral
infections. However, the phenotype of pathogenic T cells in peripheral blood remains to be
defined, and how viruses promote MS is debated. Objective We aimed to identify and
characterize potentially pathogenic autoreactive T cells, as well as protective antiviral T
cells, in patients with MS. Methods We analyzed CD4+ helper T-cell subsets from peripheral …
