[HTML][HTML] Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation
M Scarselli, B Li, SK Kim, J Wess - Journal of biological chemistry, 2007 - ASBMB
Recent studies suggest that the second extracellular loop (o2 loop) of bovine rhodopsin and
other class IG protein-coupled receptors (GPCRs) targeted by biogenic amine ligands folds
deeply into the transmembrane receptor core where the binding of cis-retinal and biogenic
amine ligands is known to occur. In the past, the potential role of the o2 loop in agonist-
dependent activation of biogenic amine GPCRs has not been studied systematically. To
address this issue, we used the M 3 muscarinic acetylcholine receptor (M3R), a prototypic …
other class IG protein-coupled receptors (GPCRs) targeted by biogenic amine ligands folds
deeply into the transmembrane receptor core where the binding of cis-retinal and biogenic
amine ligands is known to occur. In the past, the potential role of the o2 loop in agonist-
dependent activation of biogenic amine GPCRs has not been studied systematically. To
address this issue, we used the M 3 muscarinic acetylcholine receptor (M3R), a prototypic …
