The HLA-DRB1* 15: 01–restricted Goodpasture's T cell epitope induces GN
JD Ooi, J Chang, KM O'Sullivan… - Journal of the …, 2013 - journals.lww.com
Human anti-glomerular basement membrane (GBM) disease strongly associates with HLA-
DRB1* 15: 01. The target autoantigen in this disease is the noncollagenous domain of the
α3 chain of type IV collagen, α3 (IV) NC1, but critical early T cell epitopes presented by this
human MHC class II molecule are unknown. Here, by immunizing HLA-DRB1* 15: 01
transgenic mice with whole recombinant α3 (IV) NC1 and with overlapping α3 (IV) NC1
peptides, we defined a HLA-DRB1* 15: 01–restricted α3 (IV) NC1 T cell epitope (α3 136 …
DRB1* 15: 01. The target autoantigen in this disease is the noncollagenous domain of the
α3 chain of type IV collagen, α3 (IV) NC1, but critical early T cell epitopes presented by this
human MHC class II molecule are unknown. Here, by immunizing HLA-DRB1* 15: 01
transgenic mice with whole recombinant α3 (IV) NC1 and with overlapping α3 (IV) NC1
peptides, we defined a HLA-DRB1* 15: 01–restricted α3 (IV) NC1 T cell epitope (α3 136 …
