[HTML][HTML] Phosphorylation of β-catenin by cyclic AMP-dependent protein kinase
S Taurin, N Sandbo, Y Qin, D Browning… - Journal of Biological …, 2006 - ASBMB
β-Catenin is a signaling molecule that promotes cell proliferation by the induction of gene
transcription through the activation of T-cell factor (TCF)/lymphoid enhancer factor (LEF)
transcription factors. The canonical mechanism of the regulation of β-catenin involves its
phosphorylation by casein kinase 1 at the Ser-45 site and by glycogen synthase kinase 3
(GSK3) at the Thr-41, Ser-37, and Ser-33 sites. This phosphorylation targets β-catenin to
ubiquitination and degradation by the proteasome system. Mitogenic factors promote β …
transcription through the activation of T-cell factor (TCF)/lymphoid enhancer factor (LEF)
transcription factors. The canonical mechanism of the regulation of β-catenin involves its
phosphorylation by casein kinase 1 at the Ser-45 site and by glycogen synthase kinase 3
(GSK3) at the Thr-41, Ser-37, and Ser-33 sites. This phosphorylation targets β-catenin to
ubiquitination and degradation by the proteasome system. Mitogenic factors promote β …