Background & Aims Patients with chronic liver disease and cirrhosis have a dysregulated
coagulation system and are prone to thrombosis. The basis for this hypercoagulable state is
not completely understood. Tissue factor (TF) is the primary initiator of coagulation in vivo.
Patients with cirrhosis have increased TF activity in white blood cells and circulating
microparticles. The aim of our study was to determine the contribution of TF to the
hypercoagulable state in a mouse model of chronic liver injury. Methods We measured …