[HTML][HTML] HIV-1-negative female sex workers sustain high cervical IFNɛ, low immune activation, and low expression of HIV-1-required host genes
SA Abdulhaqq, C Zorrilla, G Kang, X Yin, V Tamayo… - Mucosal …, 2016 - Elsevier
Sex workers practicing in high HIV endemic areas have been extensively targeted to test
anti-HIV prophylactic strategies. We hypothesize that in women with high levels of genital
exposure to semen changes in cervico-vaginal mucosal and/or systemic immune activation
will contribute to a decreased susceptibility to HIV-1 infection. To address this question, we
assessed sexual activity and immune activation status (in peripheral blood), as well as
cellular infiltrates and gene expression in ectocervical mucosa biopsies in female sex …
anti-HIV prophylactic strategies. We hypothesize that in women with high levels of genital
exposure to semen changes in cervico-vaginal mucosal and/or systemic immune activation
will contribute to a decreased susceptibility to HIV-1 infection. To address this question, we
assessed sexual activity and immune activation status (in peripheral blood), as well as
cellular infiltrates and gene expression in ectocervical mucosa biopsies in female sex …