Splicing double: insights from the second spliceosome
AA Patel, JA Steitz - Nature reviews Molecular cell biology, 2003 - nature.com
AA Patel, JA Steitz
Nature reviews Molecular cell biology, 2003•nature.comThe genomes of most multicellular organisms contain a new class of introns that have non-
canonical consensus sequences. These minor-class introns occur extremely rarely and are
not restricted to the genes of a particular functional class.Minor-class introns are spliced by a
distinct, low-abundance splicing machinery that includes four small nuclear
ribonucleoprotein particles (snRNPs; U11, U12, U4atac and U6atac) that are functionally
analogous to the well-characterized major-class U1, U2, U4 and U6 snRNPs. The U5 …
canonical consensus sequences. These minor-class introns occur extremely rarely and are
not restricted to the genes of a particular functional class.Minor-class introns are spliced by a
distinct, low-abundance splicing machinery that includes four small nuclear
ribonucleoprotein particles (snRNPs; U11, U12, U4atac and U6atac) that are functionally
analogous to the well-characterized major-class U1, U2, U4 and U6 snRNPs. The U5 …
The genomes of most multicellular organisms contain a new class of introns that have non-canonical consensus sequences. These minor-class introns occur extremely rarely and are not restricted to the genes of a particular functional class.
Minor-class introns are spliced by a distinct, low-abundance splicing machinery that includes four small nuclear ribonucleoprotein particles (snRNPs; U11, U12, U4atac and U6atac) that are functionally analogous to the well-characterized major-class U1, U2, U4 and U6 snRNPs. The U5 snRNP is common to both spliceosomes.
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