[HTML][HTML] CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis
Background & Aims Perpetuate liver inflammation is crucial in the pathogenesis of non-
alcoholic steatohepatitis (NASH). Expression of CXCL10, a pro-inflammatory cytokine,
correlates positively with obesity and type 2 diabetes. Whether CXCL10 plays a role in
NASH was unknown. We aimed to investigate the functional and clinical impact of CXCL10
in NASH. Methods Cxcl10 gene-deleted (Cxcl10−/−) and C57BL/6 wild type (WT) mice were
fed a methionine-and choline-deficient (MCD) diet for 4 or 8 weeks. In other experiments, we …
alcoholic steatohepatitis (NASH). Expression of CXCL10, a pro-inflammatory cytokine,
correlates positively with obesity and type 2 diabetes. Whether CXCL10 plays a role in
NASH was unknown. We aimed to investigate the functional and clinical impact of CXCL10
in NASH. Methods Cxcl10 gene-deleted (Cxcl10−/−) and C57BL/6 wild type (WT) mice were
fed a methionine-and choline-deficient (MCD) diet for 4 or 8 weeks. In other experiments, we …
